![]() ![]() Direct staining of tetramers also revealed their presence in intact tissue. ![]() Gag-specific CD8+ T-cells were found in separated IELs from the rectum, colon, jejunum, and vagina of most infected animals. Of the 15 Mamu-A*01-positive macaques studied here, eight were chronically infected with either SIVmac251 or simian-human immunodeficiency virus (SHIV) KU2 and the remaining seven were exposed mucosally to SIVmac251 and sacrificed within 48 h to assess the local immune response. Here we investigated whether functional IELs in mucosal compartments could be visualized by direct staining with a tetrameric complex specific for the simian immunodeficiency virus (SIV) immunodominant Gag epitope in either separated IEL cells or tissues of macaques infected with SIVmac251. Thus, intraepithelial lymphocytes (IELs) may be important in the immune response to HIV infection. The vaginal and rectal mucosae are the first line of cellular immune defense to sexually transmitted human immunodeficiency virus type 1 (HIV-1) entry. Stevceva, Liljana Moniuszko, Marcin Alvarez, Xavier Lackner, Andrew A. ![]() International Nuclear Information System (INIS) Distinct differences in the capacity o.įunctional simian immunodeficiency virus Gag-specific CD8+ intraepithelial lymphocytes in the mucosae of SIVmac251- or simian-human immunodeficiency virus KU2-infected macaques The kinetics of these responses were similar to those observed when macrophages were treated with MIP-1β. Both HIV and SIV envelopes mobilized calcium via interactions with CCR5. The capacity of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) envelopes to transduce signals through chemokine coreceptors on macrophages was examined by measuring the ability of recombinant envelope proteins to mobilize intracellular calcium stores. Cicala, Claudia Machado, Elizabeth Wildt, Kathryne Hanbach, Meredith Steenbeke, Tavis D. CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus EnvelopesĪrthos, James Rubbert, Andrea Rabin, Ronald L. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |